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Could fused neurons explain COVID-19’s ‘brain fog’?

Researchers have demonstrated that a SARS-CoV-2 infection can induce brain cells to fuse together, with severe impacts on the functioning of neurons. Neurons may fuse together with other neurons or glia, and larger multicellular syncytia may be formed. The fusion of neurons may be one of the causes of the cognitive issues associated with COVID-19.

Ramón Martínez-Mármol et al., SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity. Sci. Adv. 9, eadg2248 (2023). DOI: 10.1126/sciadv.adg2248