mRNA vaccination against SARS-CoV-2 was tied to a 57% and 73% lower risk of having at least one or two long-COVID symptoms, respectively, in US children ages 5 to 17 years, according to a case-control study led by researchers from the Centers for Disease Control and Prevention (CDC).

The four-site study involved 622 children who were eligible for COVID-19 vaccination when they were infected with the Omicron variant and who completed a post-COVID condition (PCC) survey at least 60 days later. They were enrolled from the Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT) study, a longitudinal SARS-CoV-2 surveillance cohort convened in July 2021.