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Tag: COVID-19

New COVID-19 vaccine candidate shows strong protection against multiple variants

A promising new COVID-19 vaccine candidate developed by researchers at the Centenary Institute and the University of Sydney has shown strong potential to protect against both current and emerging coronavirus variants. By targeting features shared by a range of coronaviruses, the vaccine is designed to offer broader and longer-lasting protection as the virus continues to evolve.

The development comes as Australia faces continued COVID-19 circulation during winter, with new Omicron subvariants such as XBB.1.5 contributing to infections and hospitalisations. To date, there have been over 115,000 COVID-19 cases reported to the Australian Government’s National Notifiable Diseases Surveillance System for 2025.

Published in the scientific journal npj Vaccines, the new study shows that the vaccine candidate, named CoVEXS5, protected mice from multiple coronaviruses, including the highly immune-evasive Omicron XBB.1.5 variant and SARS-CoV-1, a relative of SARS-CoV-2 that was responsible for the 2002–2004 SARS outbreak.

In laboratory tests, CoVEXS5 reduced virus levels in the lungs of infected mice by approximately 99.9% compared to unvaccinated controls, demonstrating a dramatic protective effect.

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COVID hospitalization linked to cognitive impairment 2 years later

Almost 20% of people who were hospitalized for COVID-19 infections early in the pandemic still had signs of impairment with brain function 2 years after infection, finds a new study in Scientific Reports.

The study population came from Portugal, in a region hit hard by the first wave of the COVID-19 pandemic. Based on hospital admission episodes and SARS-CoV-2 infection status from March 2020 to February 2021, the authors identified four groups: group 1 (101) hospitalized for COVID-19 infections, group 2 (87) hospitalized but uninfected with COVID-19, group 3 (252) infected but not requiring hospitalization, and group 4 (258) uninfected and not hospitalized for any reason.

Cognitive assessments were conducted in two parts 2 years after infection, a general screening using the Montreal Cognitive Assessment and a subsequent neuropsychological assessment conducted by one of four psychologists if the score of the general screening was low. Overall, verbal memory, visual memory, executive functions, language, and information processing speed and attention were evaluated.

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Alberta wastewater unlocked key information about COVID-19. Could it help with measles too?

As Alberta’s measles outbreaks grow, researchers are now watching the province’s wastewater for the highly contagious virus and hoping to determine if the technology could eventually serve as an early detection tool.

The magnitude of Alberta’s outbreaks and the speed at which cases are climbing has sparked widespread concern. As of midday Tuesday, 1,323 cases had been confirmed since the outbreaks began in March.

Piggybacking off weekly wastewater samples, collected through the provincial COVID-19 surveillance program, the team has designed a test that can identify both the wild type measles virus (indicating actual infection) and vaccine-related shedding in the wastewater.

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‘Tremendous uncertainty’ for cancer research as US officials target mRNA vaccines

As US regulators restrict Covid mRNA vaccines and as independent vaccine advisers re-examine the shots, scientists fear that an unlikely target could be next: cancer research.

Messenger RNA, or mRNA, vaccines have shown promise in treating and preventing cancers that have often been difficult to address, such as pancreatic cancer, brain tumors and others.

But groundbreaking research could stall as federal and state officials target mRNA shots, including ending federal funding for bird flu mRNA vaccines, restricting who may receive existing mRNA vaccines and, in some places, proposing laws against the vaccines.

The Trump administration has also implemented unprecedented cuts to cancer research, among other research cuts and widespread layoffs at the National Institutes of Health (NIH).

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FDA approves Moderna COVID vaccine for kids under 12 at higher risk

Vaccine maker Moderna announced today that the US Food and Drug Administration (FDA) has granted full approval of its Spikevax (mRNA-1273) COVID vaccine for children 6 months to 11 years old. But, because federal officials in May restricted its recommendations for COVID-19 vaccines to adults 65 and older and to people of all ages who are at increased risk for severe disease, Spikevax will be available only to kids in that age range who are at higher risk.

“COVID-19 continues to pose a significant potential threat to children, especially those with underlying medical conditions. Vaccination can be an important tool for protecting our youngest against severe disease and hospitalization,” said Moderna CEO Stéphane Bancel, MBA, MEng. “We appreciate the FDA’s diligent scientific review and approval of Spikevax for pediatric populations at increased risk for COVID-19 disease.”

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Experts call new Canadian Long COVID guidelines “contradictory” and “deeply concerning”

Key points you should know:

  • The McMaster GRADE Centre and Cochrane Canada developed more than 100 recommendations for Long COVID. However, experts say some of these guidelines could harm people with Long COVID.
  • Some recommend controversial and scientifically unsupported therapies for the disease: exercise and cognitive behavioral therapy. These treatments mirror harmful and debunked recommendations for myalgic encephalomyelitis. They also contradict major guidelines.
  • The majority of pediatric guideline developers came from the same children’s hospital that parents say has psychologized their children’s symptoms. And one committee member has an inconsistently disclosed conflict of interest.
  • Professor emeritus Paul Garner attempted to influence the advisory committee, according to emails obtained through a public information access request.
  • The organizations provided only one week for public comments on the recommendations. Many people with Long COVID stopped responding because they felt their voices were not being heard.
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Medical Societies Sue Kennedy and H.H.S. Over Vaccine Advice

Six leading medical organizations filed a lawsuit on Monday against Robert F. Kennedy Jr., the health secretary, and the federal Department of Health and Human Services, charging that recent decisions limiting access to vaccines were unscientific and harmful to the public.

The suit, filed in federal court in western Massachusetts, seeks to restore Covid vaccines to the list of recommended immunizations for healthy children and pregnant women.

Mr. Kennedy has been on a “decades-long mission” to undermine vaccines and to portray them as more dangerous than the illnesses they are designed to prevent, said Richard H. Hughes IV, a lawyer who teaches vaccine law at George Washington University and is leading the effort.

“The secretary’s intentions are clear,” Mr. Hughes said: “He aims to destroy vaccines.”

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Adults who survived childhood cancer are at increased risk of severe COVID-19, says new study

People who have survived cancer as children are at higher risk of developing severe COVID-19, even decades after their diagnosis. This is shown by a new study from Karolinska Institutet published in the journal The Lancet Regional Health—Europe.

Thanks to medical advances, more and more children are surviving cancer. However, even long after treatment has ended, health risks may remain. In a new registry study, researchers investigated how adult childhood cancer survivors in Sweden and Denmark were affected by the COVID-19 pandemic.

The study included over 13,000 people who had been diagnosed with cancer before the age of 20 and who were at least 20 years old when the pandemic began. They were compared with both siblings and randomly selected individuals from the population of the same gender and year of birth.

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Public health and Icarus: what history [t]eaches about hubris and mistakes

Icarus had a problem: Desperate to escape from prison, he made wings out of feathers and wax. His father warned him not to fly too close to the sun, but Icarus couldn’t resist the freedom of soaring. His wings melted and he plunged to his death.

Like Icarus, public health is given advanced warning, but struggles between freedom and rules. And as in Greek myths, each failure offers a “moral.”

Here are five examples:

Referring to the pandemic in the past tense

COVID-19 is still spreading in unpredictable waves. Although hospitalizations are currently low, the virus landed over 1,000 Ontarians in hospital and killed nearly 500. New variants keep emerging, including the latest NB. 1.8.1, also known as “Nimbus.” It took just three months to become Canada’s dominant variant. Each time a new variant takes over, it threatens built-up immunity from vaccines and previous infections. Although Nimbus isn’t deadlier than previous variants, there’s no guarantee that future variants won’t cause more severe disease.

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How does Alberta’s new COVID-19 vaccine policy compare to other provinces? We asked

Alberta’s decision to reduce access to publicly funded COVID-19 vaccines so far appears to set the province on a different course than many other Canadian jurisdictions.

Most Albertans will no longer be eligible for a free COVID-19 shot this fall.

The provincial government recently announced plans to limit coverage to specific high-risk groups, including Albertans living in care homes and group settings, those receiving home care, people on social programs such as AISH, and immunocompromised individuals.

All other seniors, pregnant Albertans and health care workers are not included, despite strong recommendations by the National Advisory Committee on Immunization (NACI) that they should be vaccinated. NACI also recommends that everyone else may receive an annual dose.

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We will not stay silent on vaccines, say leaders of five major U.S. medical associations

The authors are the presidents of American Academy of Family Physicians, American Academy of Pediatrics, American College of Physicians, American College of Obstetricians and Gynecologists, and the Infectious Diseases Society of America.

Let us introduce ourselves. We are the doctors you trust with your health and the health of your family across every stage of life, from the first checkups in infancy and childhood, to health care during pregnancy and adulthood, through management of chronic illness and aging. We are family physicians, pediatricians, internal medicine physicians, OB-GYNs, and infectious disease experts. Our commitment is not to politics, but to the absolute well-being of our patients and populations, and to providing them with best evidence-based health care.

We have an urgent, united message: Immunizations work, they are very effective and safe, and they save lives. Vaccines are among the most rigorously studied and effective tools in public health. Through widespread immunization, we have eradicated debilitating and fatal diseases that once caused serious illness, hospitalization, and death for millions of people.

But today, that legacy is at serious risk.

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Childhood vaccines were a global success story. Misinformation and other obstacles are slowing that progress, a study shows

Routine vaccines have prevented the deaths of about 154 million children around the world over the past 50 years, a new study shows, but efforts have been slowing recently, allowing for the growth of some vaccine-preventable diseases. This backslide could lead to many more unnecessary illnesses and deaths without an increased effort to vaccinate children and counter misinformation.

The report, published Tuesday in the medical journal The Lancet, says that over the past five decades, the World Health Organization’s Expanded Programme on Immunization has vaccinated more than 4 billion children. This doubling of global coverage of vaccines has prevented countless cases of tuberculosis, measles, polio, diphtheria, tetanus and pertussis.

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Alberta government faces mounting pushback to new COVID-19 vaccine policy

The Alberta government is facing fierce and mounting opposition to plans that will reduce access to publicly funded COVID-19 vaccines in the province

The province announced late on Friday that it will limit funding of the COVID-19 shots to very specific high risk groups, including Albertans living in care homes and group settings, those receiving home care, people on social programs such as AISH, and immunocompromised individuals.

Seniors living in the community, pregnant Albertans and health-care workers will have to pay out of pocket for the vaccine, along with the rest of the population.

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UCP’s COVID vaccine cuts put children at serious risk

On May 27, the Journal of the American Medical Association Pediatrics published a patient information page about Long COVID in children. It states “Long COVID is common, affecting up to 10 per cent to 20 per cent of children with a history of COVID-19. With almost six million U.S. children potentially affected, this is higher than the number of children with asthma, the most common chronic health problem in children.”

Two weeks later on June 13, Danielle Smith’s UCP, famously fans of the anti-science Trump government, highlighted horrifically unscientific new FDA guidance suggesting healthy children and pregnant women are not recommended for COVID vaccination, while announcing a new policy where most Albertans have to pay for immunization.

Beyond the obvious inequities and loss of access that payment for prophylaxis presents, the UCP introduced a new four-phase rollout plan whereby those under age 65 without qualifying conditions cannot be vaccinated until the final phase. This means kids will likely head back to schools months before they are eligible for vaccination, ensuring they are exposed to the latest COVID strains before becoming eligible for updated vaccination. It also leaves the UCP an opening to not buy pediatric vaccines at all and claim “low demand.”

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Canada’s top doctor Theresa Tam leaving position when term ends June 20

TORONTO – As Dr. Theresa Tam prepares to leave her position next week, Canada’s top doctor says it’s more important than ever for Canada to stand up for science and combat disinformation.

She’s held the role of chief public health officer for eight years, but became a household name in the last five years as she led the country’s public health response to the COVID-19 pandemic.

Her term ends June 20 and she doesn’t have another job lined up, Tam said in a wide-ranging interview Friday that touched on her desire to be remembered for more than COVID, her passion for health equity and the musical side of her the public hasn’t seen.

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How Kennedy’s Purge of Advisers Could Disrupt U.S. Vaccinations

With two extraordinary moves, Health Secretary Robert F. Kennedy Jr. has upended the certainty that American children will always have cost-free access to lifesaving vaccines.

For decades, a little-known scientific panel at the Centers for Disease Control and Prevention has recommended which shots Americans should get and when. The group’s endorsement means insurance companies must cover the costs and helps states decide which vaccines to mandate for school-age children.

The panel, the Advisory Committee on Immunization Practices, also determines which shots are provided for free through the Vaccines for Children program, which serves about half of the children in the United States.

On Monday, Mr. Kennedy, long a vaccine skeptic, fired all 17 members of A.C.I.P., claiming that the group was rife with conflicts of interest and that a clean sweep was needed to restore public trust. Mr. Kennedy also reassigned C.D.C. staff scientists who oversee the panel’s work and vet its members.

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Kennedy dismisses entire US CDC vaccine panel, replacing all 17 members

WASHINGTON, June 9 (Reuters) – Health Secretary Robert F. Kennedy Jr. has fired all members sitting on a U.S. Centers for Disease Control and Prevention panel of vaccine experts and is reconstituting the committee, his department said on Monday.

Kennedy removed all 17 members of the Advisory Committee on Immunization Practices, the Department of Health and Human Services said in a statement, and is in the process of considering new members to replace them.

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Exclusive: CDC expert resigns from COVID vaccines advisory role, sources say

Pediatric infectious disease expert Dr. Lakshmi Panagiotakopoulos of the U.S. CDC resigned on Tuesday as co-leader of a working group that advises outside experts on COVID-19 vaccines and is leaving the agency, two sources familiar with the move told Reuters.

Panagiotakopoulos said in an email to work group colleagues that her decision to step down was based on the belief she is “no longer able to help the most vulnerable members” of the U.S. population.

In her role at the Centers for Disease Control and Prevention’s working group of the Advisory Committee on Immunization Practices, she co-led the gathering of information on topics for presentation.

Her resignation comes one week after Health Secretary Robert F. Kennedy Jr., a long-time vaccine skeptic who oversees the CDC, the Food and Drug Administration and the National Institutes of Health, said the COVID vaccine for healthy children and healthy pregnant women had been removed from the CDC’s recommended immunization schedule.

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