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Tag: research

Ontario has a globally praised system for monitoring diseases through wastewater. So why is the province shutting it down?

For the past three years, Alexandra Johnston has started her work day by reaching for the pickaxe in the trunk of her car.

It is her tool of choice for prying open manhole covers – a task she demonstrated with practised ease last week while on a tour of her wastewater sampling regimen in Toronto.

Wearing a surgical mask and gloves, Ms. Johnston dragged the heavy cover aside, then grabbed hold of the fishing line secured underneath. After hauling up a few metres of line, she displayed her catch: a dripping wet tampon she had placed there the day before.

Her teammate, Claire Gibbs, quickly moved in with a prelabelled plastic bag to capture the sewage-laden sample. Using scissors, Ms. Gibbs deftly snipped the line, sealed the bag and stowed it away in the trunk as part of that day’s delivery.

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SARS-CoV-2 widespread in Virginia wildlife, likely from people

An examination of 23 common wildlife species in Virginia finds evidence of SARS-CoV-infection in 6 and antibodies indicating previous infection in 5.

For the study, published today in Nature Communications, Virginia Tech researchers collected 789 nasal and oral swabs and 126 blood samples from animals live-trapped and released or being treated at wildlife rehabilitation centers in Virginia and Washington, DC, from May 2022 to September 2023.

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Wildfire smoke may increase the risk of dementia, study finds

A new US study has found that wildfire smoke may be worse for brain health than other types of air pollution and even increase the risk of dementia.

The findings, reported on Monday at the Alzheimer’s Association International Conference in Philadelphia, come as millions spent the weekend under air quality warnings from wildfires spewing smoke across the western US, including a huge wildfire in California that has grown to more than 360,000 acres.

At issue is fine particulate matter or PM 2.5 – tiny particles about 30 times smaller than the diameter of a human hair that can be inhaled deep into the lungs and move to the bloodstream. This pollution – from traffic, factories and fires – can cause or worsen heart and lung diseases, and the new study adds to evidence it may play some role in dementia, too.

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Long COVID puzzle pieces are falling into place – the picture is unsettling

Since 2020, the condition known as long COVID-19 has become a widespread disability affecting the health and quality of life of millions of people across the globe and costing economies billions of dollars in reduced productivity of employees and an overall drop in the work force.

The intense scientific effort that long COVID sparked has resulted in more than 24,000 scientific publications, making it the most researched health condition in any four years of recorded human history.

Long COVID is a term that describes the constellation of long-term health effects caused by infection with the SARS-CoV-2 virus. These range from persistent respiratory symptoms, such as shortness of breath, to debilitating fatigue or brain fog that limits people’s ability to work, and conditions such as heart failure and diabetes, which are known to last a lifetime.

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Wastewater testing a ‘huge scientific success’ says UW prof as province terminates network

Mark Servos is going back to studying fish.

After more than four years of testing wastewater for traces of COVID-19, the University of Waterloo fisheries biologist and his team that spans 12 universities will take their last samples next week as the country’s largest wastewater network officially disbands.

The Ministry of Environment, Conservation and Parks has terminated the program as of July 31, removing one of the last reliable trackers of the virus’s spread in communities across Ontario.

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Ontario can’t make COVID-19 disappear by pretending it doesn’t exist

Another blow to understanding the spread of COVID-19 is now slated to happen on July 31. That’s when funding ends for Ontario’s extensive wastewater surveillance program. It’s a technology that can detect viral particles up to seven days before people develop symptoms. It costs $15 million annually to check 58 sites throughout Ontario. But the cost of losing this hard-won technology is far greater. No longer having its data means that hospitals, long-term-care facilities, schools and communities will lose critical advanced warning of a potential outbreak. That gives them less time to prepare with masks, air filtration and vaccines.

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Functional neurological disorder is not an appropriate diagnosis for people with long Covid

Long Covid — the name adopted for cases of prolonged symptoms after an acute bout of Covid-19 — is an umbrella diagnosis covering a broad range of clinical presentations and abnormal biological processes. Researchers haven’t yet identified a single or defining cause for some of the most debilitating symptoms associated with long Covid, which parallel those routinely seen in other post-acute infection syndromes. These include overwhelming fatigue, post-exertional malaise, cognitive deficits (often referred to as brain fog), and extreme dizziness.

Given the current gaps in knowledge, some neurologists, psychiatrists, and other clinicians in the United States, United Kingdom, and elsewhere have suggested that an existing diagnosis known as functional neurological disorder (FND) could offer the best explanation for many cases of this devastating illness.

We strongly disagree. Although prominent news outlets such as The New Republic and Slate have promoted this perspective, it is unwarranted to view long Covid through the lens of functional neurological disorder. Despite assertions of robust evidence from those most invested in promoting it, the FND construct is based largely on speculation and assumption. Successful treatments for long Covid are much more likely to emerge from investigations into the kinds of immunological, neurological, hormonal, and vascular differences that have already been documented than from the inappropriate imposition of an often ill-fitting diagnosis onto the broad swath of people with these prolonged symptoms.

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‘Visionary’ study finds inflammation, evidence of Covid virus years after infection

Remember when we thought Covid was a two-week illness? So does Michael Peluso, assistant professor of medicine at the University of California, San Francisco.

He recalls the rush to study acute Covid infection, and the crush of resulting papers. But Peluso, an HIV researcher, knew what his team excelled at: following people over the long term.

So they adapted their HIV research infrastructure to study Covid patients. The LIINC program, short for “Long-term Impact of Infection with Novel Coronavirus,” started in San Francisco at the very beginning of the pandemic. By April 2020, the team was already seeing patients come in with lingering illness and effects of Covid — in those early days still unnamed and unpublicized as long Covid. They planned to follow people’s progress for three months after they were infected with the virus.

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NIH announces launch of clinical trial for nasal COVID vaccine

The National Institutes of Health (NIH) yesterday announced the launch of a phase 1 trial of a nasal vaccine against COVID-19, which also marks the first National Institute for Allergy and Infectious Diseases (NIAID) trial conducted as part of the government’s Project NextGen—an effort designed to advance the development of next-generation vaccines against the disease.

In an NIH statement, NIAID Director Jeanne Marrazzo, MD, said first-generation COVID vaccines have greatly mitigated the toll of the disease and are still effective for preventing severe illness, hospitalization, and death. She added, however, that they aren’t as good at preventing illness and battling milder disease.

“With the continual emergence of new virus variants, there is a critical need to develop next-generation COVID-19 vaccines, including nasal vaccines, that could reduce SARS-CoV-2 infections and transmission,” she said.

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COVID infection endangers pregnancies and newborns. Why aren’t parents being warned?

In the movie Knocked Up, Seth Rogan’s character refers to the book What to Expect When You’re Expecting as “basically a giant list of things you can’t do.” It’s a line that pokes fun at the seemingly ever-expanding list of foods, behaviors and hazards that pregnant people are encouraged to avoid in order to reduce health risks to themselves and their babies.

Despite pre-natal education’s reputation for warning new mothers of every possible danger from jumping on trampolines to eating soft cheeses, contracting a vascular virus that increases risk of pre-eclampsia, pre-term birth, miscarriage and stillbirth is being ignored. Let’s look at the evidence.

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OSPN responds to Ontario’s cut of the Wastewater Surveillance Initiative

The Ottawa Science Policy Network (OSPN) is concerned with the decision of the Ontario Government to cancel the Wastewater Surveillance Initiative (WSI) in Ontario. This cut of $15 million per year employs researchers, and offers significant returns for public health and safety.

The Wastewater Surveillance Initiative was adopted in January 2021 which led to a team of groundbreaking and internationally recognized work led by scientists at Ontario universities and research institutes. Ontario is a world leader in this field of wastewater research; tracking the impact of COVID-19 on communities through wastewater has helped shape public policy decisions and informed Ontarians of risks within the population. This funding not only provided the necessary means to track COVID-19 levels within the population but was further expanded to screen for Influenza, RSV, and M-Pox. Elizabeth Payne, a correspondent for Ottawa Citizen notes that wastewater surveillance at the start of seasonal RSV prevented 295 pediatric hospitalizations and 950 medically attended hospital visits, saving Ontario $3.5 million.

As of July 31st 2024 the Ontario government will no longer be investing in the Wastewater Surveillance Initiative, mentioning a key reason being that the Federal government will be expanding their program through the Public Health Agency of Canada. However, this leaves research groups and graduate students who rely on Ontario funding in a precarious position as the future of their funding remains uncertain.

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A new look at why old age is linked to severe, even fatal COVID

A longstanding question has nagged the COVID battle for more than four years: Why does the infection cause severe disease in older people? The question has remained despite a global cadre of medical investigators having produced some of the reasons—but not the entire story.

Ever since the beginning of the pandemic in 2020, it has been abundantly clear that older adults are at substantial risk of severe, even fatal COVID. Yet, the underlying mechanisms for their susceptibility were not always clear despite studies that took co-morbidities into account, like diabetes, heart and lung disorders, and other chronic vagaries of age that can worsen a bout with an infectious disease.

To date, scientists have blamed a dysregulated immune system, an age-related affinity toward excessive blood clotting, and an overall decline in the key soldiers of the adaptive immune system, T and B cells, to explain increased risks for severe COVID in the aging population. And while all of those factors may play a role, an inevitable question looms large: Why?

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Sudbury researcher disappointed Ontario ends COVID-19 wastewater surveillance

A researcher in Sudbury, Ont., says he’s disappointed the province is ending its wastewater surveillance program to track COVID-19 and other viruses in municipal systems.

“I would be lying if I said that I don’t feel sad to let the people go,” said Gustavo Ybazeta, a researcher at the Health Sciences North Research Institute.

Ybazeta said six people work at the lab, testing local wastewater for COVID-19 and other viruses like influenza and even sexually transmitted diseases like gonorrhea and chlamydia.

While they will continue to conduct research on ways to monitor for viruses in wastewater, losing the surveillance program means at least half of those scientists will lose their jobs, he says.

Ybazeta said there are a dozen labs across Ontario that face the same fate.

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Cutting wastewater surveillance is short-sighted

Ontario to halt COVID wastewater surveillance program, June 4

The Ontario government’s plan to axe funding for wastewater surveillance is irresponsible. Wastewater monitoring is an essential public health tool that provides insights into the spread of SARS-CoV-2, influenza and other viruses. Without funding, we will lose important information about the prevalence of these significant health concerns.

The timing of the announcement is astonishing. We are faced with an ongoing COVID-19 pandemic, and new hyper-infectious subvariants are spreading rapidly. We will be hindered in providing an early warning system to inform everyone about new subvariants and emerging pandemic threats such as avian flu.

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Ontario’s wastewater testing program to be replaced by a federal program that is significantly smaller

When Ontario’s wastewater surveillance program is shut down next month it will be replaced by a significantly smaller federal program. That potential information gap worries some researchers and public health experts, especially at a time when COVID-19 cases are starting to tick up and avian influenza is spreading rapidly.

Ontario’s wastewater testing initiative, considered a world leader, currently tests wastewater for signs of infectious diseases including COVID, influenza, RSV and more at 58 locations across the province. The provincial government plans to pull the plug on the program at the end of July, saying it wants to avoid duplication with an expanding pan-Canadian wastewater surveillance program.

That new federal program includes plans to conduct wastewater surveillance in five Ontario cities. Four of the five cities have not yet been selected.

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‘Unusual’ cancers emerged after the pandemic. Doctors ask if covid is to blame.

ROCK HILL, S.C. — Kashyap Patel looked forward to his team’s Friday lunches. All the doctors from his oncology practice would gather in the open-air courtyard under the shadow of a tall magnolia tree and catch up. The atmosphere tended to the lighthearted and optimistic. But that week, he was distressed.

It was 2021, a year into the coronavirus pandemic, and as he slid into a chair, Patel shared that he’d just seen a patient in his 40s with cholangiocarcinoma, a rare and lethal cancer of the bile ducts that typically strikes people in their 70s and 80s. Initially, there was silence, and then one colleague after another said they’d recently treated patients who had similar diagnoses. Within a year of that meeting, the office had recorded seven such cases.

“I’ve been in practice 23 years and have never seen anything like this,” Patel, CEO of Carolina Blood and Cancer Care Associates, later recalled. Asutosh Gor, another oncologist, agreed: “We were all shaken.”

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Ontario is a ‘world leader’ in wastewater surveillance for COVID. The province’s decision to close testing sites will end that, experts say

Researchers are warning that Ontario’s decision to shut down its wastewater surveillance program that proved crucial in tracking COVID-19 will limit the province’s ability to rapidly respond to infectious disease threats, including new COVID variants, respiratory viruses and bird flu.

A key member of the waterwater surveillance program says Ontario has been a “world leader and now we’ll probably be one of the passengers” by the scale-back that will also stifle research.

Cancelling the provincial surveillance system — the largest in Canada — will drastically reduce the number of testing sites in the province, experts say. They also caution that shuttering the program will mean that monitoring may no longer take place in smaller communities and in rural and northern areas, potentially missing vulnerable populations.

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