The Vaccine and Infectious Disease Organization (VIDO) at the University of Saskatchewan has been awarded a $24 million grant to help develop a vaccine to protect against wide-ranging strains of coronaviruses.
VIDO’s funding flows from Norwegian-based Coalition for Epidemic Preparedness Innovations (CEPI) into its ongoing development of its pan-sarbecovirus vaccine.
Comments closedThe National Science Foundation canceled all of its grant review panels this week, as the organization works to align its grantmaking process with new executive orders from the Trump administration.
The NSF funds a wide range of scientific research through grants to universities and research institutions. It convenes panels of experts to weigh the merits of those proposals, ultimately informing which receive federal funding. It has a budget of around $9 billion.
Comments closedResearchers have discovered a molecular signature of Long Covid in children, detectable through a blood test and diagnosable with 93% accuracy using AI.
This breakthrough signifies a major advancement in pediatric healthcare, offering hope for early detection and tailored treatments.
Comments closedA flurry of scientific gatherings and panels across federal science agencies were canceled on Wednesday, at a time of heightened sensitivity about how the Trump administration will shift the agencies’ policies and day-to-day affairs.
Several meetings of National Institutes of Health study sections, which review applications for fellowships and grants, were canceled without being rescheduled, according to agency notices reviewed by STAT. A Feb. 20-21 meeting of the National Vaccine Advisory Committee, a panel that advises the leadership of the Department of Health and Human Services on vaccine policy, was also canceled. So was a meeting of the Presidential Advisory Council for Combating Antibiotic-Resistant Bacteria that was scheduled for Jan. 28 and 29.
Comments closedResearchers from the Institute of Science Tokyo and Osaka Medical and Pharmaceutical University said that they have developed a peptide that can bind to the spike proteins of SARS-CoV-2 to prevent COVID-19 infections.
The peptide, which is a short chain of amino acids, has shown effectiveness in experiments involving various coronavirus strains attempting to infect human cell lines and hamsters.
Researchers hope to conduct a physician-led clinical trial for possible preventive and therapeutic treatment.
Comments closedThe Trump administration has instructed federal health agencies to pause all external communications, such as health advisories, weekly scientific reports, updates to websites and social media posts, according to nearly a dozen current and former officials and other people familiar with the matter.
The instructions were delivered Tuesday to staff at agencies inside the Department of Health and Human Services, including the Food and Drug Administration, the Centers for Disease Control and Prevention and the National Institutes of Health, one day after the new administration took office, according to the people with knowledge, who spoke on the condition of anonymity to describe private conversations. Some of them acknowledged that they expected some review during a presidential transition but said they were confused by the pause’s scope and indeterminate length.
The health agencies are charged with making decisions that touch the lives of every American and are the source of crucial information to health-care providers and organizations across the country.
Comments closedA new study that identified 475 patients with post-acute sequelae of COVID-19 (PASC), also known as long COVID, revealed that nearly 85% (403) of these patients had multiple COVID-19 infections over the course of a four-year period (March 2020 to February 2024). Additionally, vaccination independently reduced the risk of long COVID in patients who had received the vaccination prior to contracting the infection.
Comments closedNew results from the National Institutes of Health’s Researching COVID to Enhance Recovery (RECOVER)-Adult Initiative suggest that 4.5% of COVID-19 survivors have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), compared with less than 1% of their uninfected counterparts.
ME/CFS, which can be triggered by viral and non-viral infection, causes severe fatigue for at least 6 months and may entail impaired memory, brain fog, dizziness, and muscle or joint pain. Physical or mental activity exacerbates symptoms, which aren’t fully relieved by rest.
RECOVER-Adult is a longitudinal observational study conducted at 83 sites in 33 states, Puerto Rico, and Washington, DC, to research post-COVID conditions such as ME/CFS and long COVID.
Comments closedComments closedSimply put, COVID-19 infections weaken our immune systems. This makes us more prone to reinfection with SARS-CoV-2, infections with other viruses (e.g. RSV), reactivation of dormant viral infections (e.g. shingles, Herpes-Zoster virus), bacterial infections (Group A strep,TB) and even rare fungal infections. To make matters worse, the infections themselves may also be more severe. Being infected with SARS-CoV-2 and other viruses or bacteria at the same time can also make things worse, in adults as well as children.
The COVID-19 pandemic highlighted how crucial testing is for disease preparedness and response, and new research from the Johns Hopkins Applied Physics Laboratory (APL) and a team of collaborators underscores that principle.
Published in the Jan. 2 edition of The Lancet Public Health, the research included simulation and analysis that suggests public-private partnerships to develop, produce and distribute COVID-19 diagnostic tests saved an estimated 1.4 million lives and prevented about 7 million patient hospitalizations in the United States during the pandemic.
Comments closedWe’re learning more about the B.C. teenager who became the first critically ill pediatric patient with avian influenza in North America earlier this fall, including some details about her recovery.
The new information was published in a case summary as a letter to the editor of the New England Journal of Medicine on Tuesday, signed by multiple doctors from the B.C. Centre for Disease Control, BC Children’s Hospital and Public Health Agency of Canada.
Prior to the publication of the letter, B.C.’s Ministry of Health had refused to provide updates on the teen’s status or their case “unless there is a need from a public health perspective to do so.”
Comments closedLong COVID is snuffing out some patients’ dreams of having children, sharpening the pain of loss, grief and medical neglect.
When Melanie Broadley and her husband started going out in 2019, like many couples their age they decided to put “starting a family” on the shelf for a few years so they could focus on their careers. A postdoctoral researcher who studies diabetes and psychology, Broadley was 28 and in good health — she had plenty of time, she reasoned. Then, in 2022, she caught SARS-CoV-2 and developed long COVID, blowing up her life as she knew it and, for now at least, her hopes of having a baby.
“I became totally disabled by long COVID,” says Broadley, 34, who lives at her parents’ house in Brisbane. On a good day she struggles with debilitating fatigue that worsens after any kind of physical or mental activity, an autonomic nervous system disorder called postural orthostatic tachycardia syndrome (POTS), which causes her heart rate to spike when she stands up, cognitive dysfunction that means she can’t read or write for more than 10 minutes at a time, and an immune disorder, called mast cell activation syndrome, that triggers allergic reactions. Even though she’s been doing everything she can to recover, she’s still too unwell to cope with a potential pregnancy.
Comments closedGenetic sequences of H5N1 bird flu viruses collected from a person in Louisiana who became severely ill show signs of development of several mutations thought to affect the virus’ ability to attach to cells in the upper airways of humans, the Centers for Disease Control and Prevention reported on Thursday.
One of the mutations was also seen in a virus sample taken from a teenager in British Columbia who was in critical condition in a Vancouver hospital for weeks after contracting H5N1.
The mutation seen in both viruses is believed to help H5N1 adapt to be able to bind to cell receptors found in the upper respiratory tracts of people. Bird flu viruses normally attach to a type of cell receptor that is rare in human upper airways, which is believed to be one of the reasons why H5N1 doesn’t easily infect people and does not spread from person-to-person when it does.
Comments closedTwo new studies paint a comprehensive picture of current long COVID cases in the United States, and both suggest the condition limits daily activities for a significant proportion of those affected.
Comments closedThe United States has a health-care system that is terrible and getting worse. It also has a health science system that is the best in the world and about to be dismantled.
The impending return of Donald Trump to the White House seems likely to collapse American health science, with consequences as disastrous for the rest of the world as for the approximately 340 million Americans in the U.S. Canada may be able to soften the impact here, but it will not be easy.
Comments closed“Concerns have been raised” relating to respect for “publication ethics” of the journal’s publisher, and “the appropriate conduct of research involving human participants, as well as concerns raised by three of the authors themselves regarding the article’s methodology and conclusions,” stated Elsevier, the publisher of the scientific journal International Journal of Antimicrobial Agents, in a lengthy note justifying this rare retraction.
The article, signed by 18 authors, notably Philippe Gautret, then a professor at the Marseille IHU, and Didier Raoult, who directed this institute, intended to demonstrate the efficacy of hydroxychloroquine, combined with an antibiotic – azithromycin – against COVID-19.
Comments closedA new study published in BMC Cardiovascular Disorders shows that pediatric and young adult COVID-19 patients are more at risk for cardiac complications than flu or RSV patients of the same age.
The study was based on hospitalized US patients from 2020 through 2021 tracked through the National Inpatient Sample. In total 212,655 respiratory virus admissions were recorded, including 85,055 from COVID-19, 103,185 from RSV, and 24,415 from influenza.
Comments closedWastewater in Guelph will continue to be monitored for COVID-19, influenza and other illnesses through a new partnership between researchers at the University of Guelph and Wellington-Dufferin-Guelph Public Health.
The researchers will get samples of wastewater three times a week, then will submit their findings to public health, which will in turn publish it to a public online dashboard.
Provincial funding for wastewater testing was cut on July 31 with the Ontario government citing a federal program that tests wastewater; however, none of the testing sites are in Waterloo region or Guelph.
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