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Tag: University of Toronto

There’s a gaping hole in Canada’s COVID tracking

The Government of Canada’s website tracks the number of hospitalizations and deaths from acute COVID-19. What it fails to include are the hospitalizations and deaths that result from COVID’s longer-term health consequences.

Even mild cases carry risk, but COVID most frequently wallops people after severe cases, especially when hospitalized. Of the nearly 300,000 Canadians hospitalized so far, over half likely have — or will — suffer life-changing health consequences, sometimes years after having recovered from the acute illness. These risks climb with repeated infections.

Hospitalizations and deaths from COVID-19 are often delayed. Like high blood pressure, SARS CoV-2 can gradually damage the inner lining of blood vessels. This by itself, is painless. While it happens to people following mild cases of COVID, it’s far more likely after severe ones, especially after hospitalization. This doubles the downstream risk of having a heart attack, stroke or blood clot in the lung. It triples the risk of developing an abnormal heart rhythm, including atrial fibrillation.

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COVID-19 virus disrupts protein production, study finds

When SARS-CoV-2 enters our cells, it disrupts the process of making proteins, which are essential for our cells to work correctly. A particular SARS-CoV-2 protein called Nsp1 has a crucial role in this process. It stops ribosomes, the machinery that makes proteins, from doing their job effectively. The virus is like a clever saboteur inside our cells, making sure its own needs are met while disrupting our cells’ ability to defend themselves.

— Talya Yerlici, a post-doctoral researcher at the University of Toronto’s Temerty Faculty of Medicine
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