A US modeling study published yesterday in JAMA Pediatrics estimates that vaccinating pregnant women against COVID-19 prevented 7,000 hospitalizations in infants and 3,000 in pregnant women from January 2024 to May 2025.

The Stanford University–led research team analyzed COVID-NET surveillance data on COVID-19 hospitalization rates in infants younger than 6 months and incidence data on pregnant women aged 18 to 49 years under a relative risk of 2.65. The aim was to estimate the health impact of vaccination during pregnancy, mainly during the second or third trimester.

The team also used recent COVID-19 vaccine effectiveness (VE) estimates, including a 35% reduction in COVID-19 hospitalization risk in young infants and a 33% VE in adults.