Cancer survivors infected with COVID-19 in the early months of the pandemic had a higher risk of dying from dormant cells reawakening, Colorado researchers found, though they don’t know whether people who get the virus now face the same risk.
Experiments in mice found that genetically modified animals were more likely to have signs of metastatic cancer in their lungs if infected with flu or COVID-19 than engineered mice that researchers didn’t give a virus, said James DeGregori, deputy director of the University of Colorado Cancer Center in Aurora.
That finding launched an international partnership to determine whether the same thing happened in people, he said.
DeGregori was one of the lead investigators, alongside scientists from Utrecht University in the Netherlands, Imperial College London, University College London, University of Connecticut, Albert Einstein College of Medicine in New York City, Children’s Hospital of Philadelphia, and the COVID-19 International Research Team, based in Massachusetts.
Two datasets, from the United States and the United Kingdom, both showed a higher risk that cancer survivors with confirmed COVID-19 infections would die from metastatic cancer, compared to survivors who didn’t test positive for the virus.
The British data showed people who tested positive had about twice the risk of those who tested negative, and the American data showed about a 44% increased risk, DeGregori said. A significant number of the U.S. patients never got tested for COVID-19, however, so the risk was likely higher because of cancer deaths in people with missed infections, he said.
The American data only included breast cancer survivors, while the British data included people who were in remission from any type of cancer. The risk of death was highest in the months immediately after an infection.
COVID-19 didn’t directly cause the cancer to spread, but created an environment where dormant cells elsewhere in patients’ bodies can wake up, DeGregori said. The body responds to an infection with inflammation to kill the virus, which helps the cancer cells, he said.