Work-related factors may increase the risk of developing long COVID, according to a new population-based study from Spain.
The findings, published in BMJ Occupational & Environmental Medicine, suggest that the primary work-related drivers of increased long COVID risk were irregular or limited use of respirators, close contact with coworkers and/or the public, inability to physical distance, and use of public transportation to commute to work.
Comments closedWork-related factors play a significant and independent role in the risk of developing Long-COVID, shows a new study based on the COVICAT cohort and led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by “la Caixa” Foundation, in collaboration with the University of Turin and the Germans Trias i Pujol Institute (IGTP). The findings, published in BMJ Occupational & Environmental Medicine, highlight that a substantial share of Long-COVID could be prevented through targeted workplace measures and policies.
The public health impact of Long-COVID is far from over. Beyond ongoing infections that continue to cause illness and deaths worldwide, millions of people are living with lasting health consequences. Globally, around 6 in every 100 COVID-19 cases develop Long-COVID, amounting to 400 million affected people and an annual economic impact of roughly 1 trillion dollars, or 1% of the global economy.
Comments closedIn a major boost to research on long COVID and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), the German government has announced that it will provide €500 million (US$582 million) in research funding to support a National Decade Against Post-Infectious Diseases from 2026 to 2036.
Germany is one of many countries facing an unprecedented health burden owing to long COVID and other post-infection syndromes since the COVID-19 pandemic. Almost one in five people in a German cohort had long COVID in 2022, and around one in seven people in the United States were affected by long COVID by late 2023. This translates to a considerable burden on health care and the economy — the syndrome is estimated to cost the world economy US$1 trillion every year.
Comments closedCOVID-19 vaccines have not caused an increase in mortality in France since their appearance in the early 2020s, according to a study that refutes the widespread false theories prevalent in vaccine skeptic circles.
“COVID messenger RNA [mRNA] vaccines do not increase the long-term risk of all-cause mortality,” states Epi-Phare, a French organization comprising the Agence nationale de sécurité du médicament (ANSM) and Assurance maladie, in a study published in JAMA Network Open (opens in a new window).
To reach these conclusions, its authors examined data from nearly 30 million French people between 2021 and 2025, representing the entire 18-59 age group.
Comments closedFormer British prime minister Boris Johnson oversaw a “toxic,” “chaotic” and dithering response to the COVID-19 pandemic, with a delay in locking the country down resulting in about 23,000 more deaths, a report by a public inquiry concluded on Thursday.
Britain recorded more than 230,000 deaths from COVID, a similar death rate to the United States and Italy but higher than elsewhere in western Europe, and it is still recovering from the economic consequences.
An inquiry, which Johnson ordered in May 2021, delivered a blistering assessment of his government’s response to the pandemic, criticizing his indecisive leadership, lambasting his Downing Street office for breaking their own rules and castigating his top adviser, Dominic Cummings.
Comments closedResults from a single-center randomized controlled trial published yesterday in JAMA Internal Medicine show that azelastine, an antihistamine nasal spray used as a preventive measure, was associated with a 69% reduction of COVID-19 infection.
Azelastine is a widely available over-the-counter treatment for seasonal allergies (hay fever).
“This clinical trial is the first to demonstrate a protective effect in a real-world setting,” said Robert Bals, MD, PhD, a professor at Saarland University in Germany and senior author of the study, in a university press release.
Comments closedChoking smoke spewed by wildfires is far more dangerous than previously thought, a new study has found, with death tolls from short-term exposure to fine particulates underestimated by 93%.
Researchers found that 535 people in Europe died on average each year between 2004 and 2022 as a result of breathing in the tiny toxic particles known as PM2.5 that are released when wildfires rage.
Under standard methods, which assume PM2.5 from wildfires is as deadly as from other sources, such as traffic, they would have expected just 38 deaths a year.
Comments closedEli Lilly said Thursday that it would increase the prices of medicines in Europe and other developed markets “in order to make them lower” in the U.S., an apparent response to the Trump administration’s calls to do so. It singled out the list price of its popular weight-loss drug in the U.K. as part of that effort.
The announcement is among the first moves by a major drugmaker to raise prices abroad in order to lower them in the U.S., in line with President Trump’s agenda. But it’s not clear if these actions would actually increase the amount of revenue that Lilly earns abroad, since governments and private providers that cover drugs often negotiate discounts off the list prices. Lilly did not immediately announce any new price reductions in the U.S.
Comments closedGroundbreaking research led by a Swansea University academic has revealed a synthetic glycosystem — a sugar-coated polymer nanoparticle — that can block Covid-19 from infecting human cells, reducing infection rates by nearly 99%.
The glycosystem is a specially designed particle that mimics natural sugars found on human cells. These sugars, known as polysialosides, are made of repeating units of sialic acid — structures that viruses often target to begin infection. By copying this structure, the synthetic molecule acts as a decoy, binding to the virus’s spike protein and preventing it from attaching to real cells.
Unlike vaccines, which trigger immune responses, this molecule acts as a physical shield, offering a novel approach to infection prevention.
Comments closedThe 2024-25 COVID mRNA vaccines targeting JN.1 were highly effective in protecting against hospitalization and death for at least 4 months in a cohort of Danish citizens aged 65 and older by October 1, 2024. The new analysis estimating the vaccine efficacy (VE) of last season’s COVID vaccines was published earlier this week in The Lancet Infectious Diseases.
In total, 894,560 Danish residents were included in the study, with a median age of 76. By Jan 31, 2025, 820,229 (91.7%) of the participants had received a JN.1 vaccine. Among those without updated JN.1 vaccination (74,331), 278 COVID-19 hospitalizations and 84 deaths were observed during 25.6 million person-days.
Comments closedAlmost 20% of people who were hospitalized for COVID-19 infections early in the pandemic still had signs of impairment with brain function 2 years after infection, finds a new study in Scientific Reports.
The study population came from Portugal, in a region hit hard by the first wave of the COVID-19 pandemic. Based on hospital admission episodes and SARS-CoV-2 infection status from March 2020 to February 2021, the authors identified four groups: group 1 (101) hospitalized for COVID-19 infections, group 2 (87) hospitalized but uninfected with COVID-19, group 3 (252) infected but not requiring hospitalization, and group 4 (258) uninfected and not hospitalized for any reason.
Cognitive assessments were conducted in two parts 2 years after infection, a general screening using the Montreal Cognitive Assessment and a subsequent neuropsychological assessment conducted by one of four psychologists if the score of the general screening was low. Overall, verbal memory, visual memory, executive functions, language, and information processing speed and attention were evaluated.
Comments closedRoutine vaccines have prevented the deaths of about 154 million children around the world over the past 50 years, a new study shows, but efforts have been slowing recently, allowing for the growth of some vaccine-preventable diseases. This backslide could lead to many more unnecessary illnesses and deaths without an increased effort to vaccinate children and counter misinformation.
The report, published Tuesday in the medical journal The Lancet, says that over the past five decades, the World Health Organization’s Expanded Programme on Immunization has vaccinated more than 4 billion children. This doubling of global coverage of vaccines has prevented countless cases of tuberculosis, measles, polio, diphtheria, tetanus and pertussis.
Comments closedResearchers in Denmark conducted a large-scale evaluation of the disease burdens associated with COVID-19 and influenza. Their conclusion? COVID-19 has a greater impact than influenza, resulting in more hospitalizations and deaths. These findings, they note, emphasize the continued need for a strong public health response.
To compare the disease burden of COVID-19 and influenza, the researchers evaluated data available from Danish health registries from May 16, 2022 to June 7, 2024. The results were published in The Lancet Infectious Diseases. A commentary about the findings was published in the same issue of the journal.
During this period, the risk of hospitalization due to COVID-19 was approximately two times higher than the risk of hospitalization due to influenza. The risk of death was approximately three times higher. The researchers note that these increased risks were greater during the first year of the study period but still were evident during the second year. The risk of mortality, for example, was five times greater for COVID-19 during the first year of the study. That increased risk dropped during the second year, but COVID-19 still had a two and a half times greater risk of mortality than influenza.
Comments closedAs the Trump administration cut billions of dollars in federal funding to scientific research, thousands of scientists in the U.S. lost their jobs or grants…
Comments closedCOVID-19 vaccination reduced the risk of developing ‘long COVID’ by approximately 27% in adults fully vaccinated before infection, according to a literature review carried out…
Comments closedPeople who later experienced persistent shortness of breath or fatigue after a COVID infection were already taking significantly fewer steps per day and had a higher resting heart rate before contracting the virus, according to a CSH study published in npj Digital Medicine. This may indicate lower fitness levels or pre-existing conditions as potential risk factors
Between April 2020 and December 2022, over 535,000 people in Germany downloaded and activated the Corona Data Donation App (CDA). Of these, more than 120,000 voluntarily shared daily data from their smartwatches and fitness trackers with researchers, providing insights into vital functions such as resting heart rate and step count.
“These high-resolution data served as the starting point for our study,” explains CSH researcher Katharina Ledebur. “We were able to compare vital signs in 15-minute intervals before, during, and after a SARS-CoV-2 infection.”
Comments closedIn a Swedish cohort, the risk of long COVID was much lower for vaccinated than unvaccinated participants in the year after infection, even when restricting the analyses to subgroups based on variant, age, sex, and previous infection status, estimates a study published last week in the Journal of Infectious Diseases.
Karolinska Institutet researchers in Stockholm analyzed data from five registries to compare rates of persistent COVID-19 symptoms, or post-COVID condition [PCC], in adults infected from January 2021 to February 2022 by vaccination status in the 14 days before infection. Follow-up was 365 to 660 days.
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