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Tag: research

Long COVID leads to missed work days, economic loss

About 14% of participants in a new long-COVID study from Yale said they didn’t return to work in the months after their infection, suggesting that the condition results in major economic losses. The study is published in PLOS One.

The study was based on the outcomes of 6,000 participants at eight study sites in Illinois, Connecticut, Washington, Pennsylvania, Texas, and California from 2020 through 2022 as part of the Innovative Support for Patients with SARS-CoV-2 Infections Registry, or INSPIRE study.

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New studies estimate long-COVID rates, identify risk factors

As new variants continue to emerge and infect people, older adults remain highly vulnerable to long-term health effects from this pathogen. Continued multidisciplinary research is needed to understand and prevent long COVID to reduce morbidity and mortality and maintain quality of life in older adults.

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About 400 Million People Worldwide Have Had Long Covid, Researchers Say

About 400 million people worldwide have been afflicted with long Covid, according to a new report by scientists and other researchers who have studied the condition. The team estimated that the economic cost — from factors like health care services and patients unable to return to work — is about $1 trillion worldwide each year, or about 1 percent of the global economy.

The report, published Friday in the journal Nature Medicine, is an effort to summarize the knowledge about and effects of long Covid across the globe four years after it first emerged.

It also aims to “provide a road map for policy and research priorities,” said one author, Dr. Ziyad Al-Aly, the chief of research and development at the V.A. St. Louis Health Care System and a clinical epidemiologist at Washington University in St. Louis. He wrote the paper with several other leading long Covid researchers and three leaders of the Patient-Led Research Collaborative, an organization formed by long Covid patients who are also professional researchers.

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Long COVID is a $1 trillion problem with no cure. Experts plead for governments to wake up

For months, governmental officials around the world have appeared to want to forgo discussing the specter of long COVID. As a new review makes clear, that is wishful thinking—and the latest COVID variants may well kick long COVID into overdrive, a scenario that researchers and experts have been warning about for some time.

“I think they (government agencies) are itching to pretend that COVID is over and that long COVID does not exist,” says Ziyad Al-Aly, director of the Clinical Epidemiology Center at Veterans Affairs St. Louis Health Care System and lead author of the review. “It is much more pleasant to pretend as if emergency department visits and hospitalizations haven’t been rising sharply this summer.”

In a Nature Medicine review this week, Al-Aly and several other top researchers lay out a difficult truth: Long COVID has already affected an estimated 400 million people worldwide, a number the authors say is likely conservative, at an economic cost of about $1 trillion annually—equivalent to 1% of the global economy.

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Sanders Proposes ‘Moonshot’ Bill to Combat Long Covid Crisis

For far too long, millions of Americans suffering from long Covid have had their symptoms dismissed or ignored — by the medical community, by the media, and by Congress. That is unacceptable and has got to change.

The legislation that we have introduced finally recognizes that long Covid is a public health emergency and provides an historic investment into research, development, and education needed to counter the effects of this terrible disease. Congress must act now to ensure treatments are developed and made available for Americans struggling with long Covid. Yes. It is time for a long Covid moonshot.

— U.S. Senator Bernie Sanders, chair of the Senate Committee on Health, Education, Labor, and Pensions (HELP)
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The Risks of Killing a COVID Early Warning System

COVID-19 is surging in parts of North America and Europe, and even played a role in ending the presidential campaign of 81-year-old Joe Biden, who was infected for the third time last month.

Nevertheless, on Wednesday the Ontario government shut down its early warning system to detect COVID and other emerging diseases.

Doctors, citizens and researchers are calling the decision to kill the province’s wastewater disease surveillance program both wrong-headed and dangerous. Ending the program will make it harder to track and thwart viral outbreaks, they say, and thereby increase the burden on Ontario’s understaffed hospitals, which experienced more than 1,000 emergency room closures last year.

“Pandemics do not end because science has been muzzled,” Dr. Iris Gorfinkel, a well-known Toronto physician and clinical researcher, told the CBC.

In emails to politicians, more than 5,000 citizens have demanded restoration of the program, with little effect.

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Ontario has a globally praised system for monitoring diseases through wastewater. So why is the province shutting it down?

For the past three years, Alexandra Johnston has started her work day by reaching for the pickaxe in the trunk of her car.

It is her tool of choice for prying open manhole covers – a task she demonstrated with practised ease last week while on a tour of her wastewater sampling regimen in Toronto.

Wearing a surgical mask and gloves, Ms. Johnston dragged the heavy cover aside, then grabbed hold of the fishing line secured underneath. After hauling up a few metres of line, she displayed her catch: a dripping wet tampon she had placed there the day before.

Her teammate, Claire Gibbs, quickly moved in with a prelabelled plastic bag to capture the sewage-laden sample. Using scissors, Ms. Gibbs deftly snipped the line, sealed the bag and stowed it away in the trunk as part of that day’s delivery.

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SARS-CoV-2 widespread in Virginia wildlife, likely from people

An examination of 23 common wildlife species in Virginia finds evidence of SARS-CoV-infection in 6 and antibodies indicating previous infection in 5.

For the study, published today in Nature Communications, Virginia Tech researchers collected 789 nasal and oral swabs and 126 blood samples from animals live-trapped and released or being treated at wildlife rehabilitation centers in Virginia and Washington, DC, from May 2022 to September 2023.

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Wildfire smoke may increase the risk of dementia, study finds

A new US study has found that wildfire smoke may be worse for brain health than other types of air pollution and even increase the risk of dementia.

The findings, reported on Monday at the Alzheimer’s Association International Conference in Philadelphia, come as millions spent the weekend under air quality warnings from wildfires spewing smoke across the western US, including a huge wildfire in California that has grown to more than 360,000 acres.

At issue is fine particulate matter or PM 2.5 – tiny particles about 30 times smaller than the diameter of a human hair that can be inhaled deep into the lungs and move to the bloodstream. This pollution – from traffic, factories and fires – can cause or worsen heart and lung diseases, and the new study adds to evidence it may play some role in dementia, too.

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Long COVID puzzle pieces are falling into place – the picture is unsettling

Since 2020, the condition known as long COVID-19 has become a widespread disability affecting the health and quality of life of millions of people across the globe and costing economies billions of dollars in reduced productivity of employees and an overall drop in the work force.

The intense scientific effort that long COVID sparked has resulted in more than 24,000 scientific publications, making it the most researched health condition in any four years of recorded human history.

Long COVID is a term that describes the constellation of long-term health effects caused by infection with the SARS-CoV-2 virus. These range from persistent respiratory symptoms, such as shortness of breath, to debilitating fatigue or brain fog that limits people’s ability to work, and conditions such as heart failure and diabetes, which are known to last a lifetime.

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Wastewater testing a ‘huge scientific success’ says UW prof as province terminates network

Mark Servos is going back to studying fish.

After more than four years of testing wastewater for traces of COVID-19, the University of Waterloo fisheries biologist and his team that spans 12 universities will take their last samples next week as the country’s largest wastewater network officially disbands.

The Ministry of Environment, Conservation and Parks has terminated the program as of July 31, removing one of the last reliable trackers of the virus’s spread in communities across Ontario.

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Ontario can’t make COVID-19 disappear by pretending it doesn’t exist

Another blow to understanding the spread of COVID-19 is now slated to happen on July 31. That’s when funding ends for Ontario’s extensive wastewater surveillance program. It’s a technology that can detect viral particles up to seven days before people develop symptoms. It costs $15 million annually to check 58 sites throughout Ontario. But the cost of losing this hard-won technology is far greater. No longer having its data means that hospitals, long-term-care facilities, schools and communities will lose critical advanced warning of a potential outbreak. That gives them less time to prepare with masks, air filtration and vaccines.

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Functional neurological disorder is not an appropriate diagnosis for people with long Covid

Long Covid — the name adopted for cases of prolonged symptoms after an acute bout of Covid-19 — is an umbrella diagnosis covering a broad range of clinical presentations and abnormal biological processes. Researchers haven’t yet identified a single or defining cause for some of the most debilitating symptoms associated with long Covid, which parallel those routinely seen in other post-acute infection syndromes. These include overwhelming fatigue, post-exertional malaise, cognitive deficits (often referred to as brain fog), and extreme dizziness.

Given the current gaps in knowledge, some neurologists, psychiatrists, and other clinicians in the United States, United Kingdom, and elsewhere have suggested that an existing diagnosis known as functional neurological disorder (FND) could offer the best explanation for many cases of this devastating illness.

We strongly disagree. Although prominent news outlets such as The New Republic and Slate have promoted this perspective, it is unwarranted to view long Covid through the lens of functional neurological disorder. Despite assertions of robust evidence from those most invested in promoting it, the FND construct is based largely on speculation and assumption. Successful treatments for long Covid are much more likely to emerge from investigations into the kinds of immunological, neurological, hormonal, and vascular differences that have already been documented than from the inappropriate imposition of an often ill-fitting diagnosis onto the broad swath of people with these prolonged symptoms.

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‘Visionary’ study finds inflammation, evidence of Covid virus years after infection

Remember when we thought Covid was a two-week illness? So does Michael Peluso, assistant professor of medicine at the University of California, San Francisco.

He recalls the rush to study acute Covid infection, and the crush of resulting papers. But Peluso, an HIV researcher, knew what his team excelled at: following people over the long term.

So they adapted their HIV research infrastructure to study Covid patients. The LIINC program, short for “Long-term Impact of Infection with Novel Coronavirus,” started in San Francisco at the very beginning of the pandemic. By April 2020, the team was already seeing patients come in with lingering illness and effects of Covid — in those early days still unnamed and unpublicized as long Covid. They planned to follow people’s progress for three months after they were infected with the virus.

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NIH announces launch of clinical trial for nasal COVID vaccine

The National Institutes of Health (NIH) yesterday announced the launch of a phase 1 trial of a nasal vaccine against COVID-19, which also marks the first National Institute for Allergy and Infectious Diseases (NIAID) trial conducted as part of the government’s Project NextGen—an effort designed to advance the development of next-generation vaccines against the disease.

In an NIH statement, NIAID Director Jeanne Marrazzo, MD, said first-generation COVID vaccines have greatly mitigated the toll of the disease and are still effective for preventing severe illness, hospitalization, and death. She added, however, that they aren’t as good at preventing illness and battling milder disease.

“With the continual emergence of new virus variants, there is a critical need to develop next-generation COVID-19 vaccines, including nasal vaccines, that could reduce SARS-CoV-2 infections and transmission,” she said.

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COVID infection endangers pregnancies and newborns. Why aren’t parents being warned?

In the movie Knocked Up, Seth Rogan’s character refers to the book What to Expect When You’re Expecting as “basically a giant list of things you can’t do.” It’s a line that pokes fun at the seemingly ever-expanding list of foods, behaviors and hazards that pregnant people are encouraged to avoid in order to reduce health risks to themselves and their babies.

Despite pre-natal education’s reputation for warning new mothers of every possible danger from jumping on trampolines to eating soft cheeses, contracting a vascular virus that increases risk of pre-eclampsia, pre-term birth, miscarriage and stillbirth is being ignored. Let’s look at the evidence.

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OSPN responds to Ontario’s cut of the Wastewater Surveillance Initiative

The Ottawa Science Policy Network (OSPN) is concerned with the decision of the Ontario Government to cancel the Wastewater Surveillance Initiative (WSI) in Ontario. This cut of $15 million per year employs researchers, and offers significant returns for public health and safety.

The Wastewater Surveillance Initiative was adopted in January 2021 which led to a team of groundbreaking and internationally recognized work led by scientists at Ontario universities and research institutes. Ontario is a world leader in this field of wastewater research; tracking the impact of COVID-19 on communities through wastewater has helped shape public policy decisions and informed Ontarians of risks within the population. This funding not only provided the necessary means to track COVID-19 levels within the population but was further expanded to screen for Influenza, RSV, and M-Pox. Elizabeth Payne, a correspondent for Ottawa Citizen notes that wastewater surveillance at the start of seasonal RSV prevented 295 pediatric hospitalizations and 950 medically attended hospital visits, saving Ontario $3.5 million.

As of July 31st 2024 the Ontario government will no longer be investing in the Wastewater Surveillance Initiative, mentioning a key reason being that the Federal government will be expanding their program through the Public Health Agency of Canada. However, this leaves research groups and graduate students who rely on Ontario funding in a precarious position as the future of their funding remains uncertain.

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A new look at why old age is linked to severe, even fatal COVID

A longstanding question has nagged the COVID battle for more than four years: Why does the infection cause severe disease in older people? The question has remained despite a global cadre of medical investigators having produced some of the reasons—but not the entire story.

Ever since the beginning of the pandemic in 2020, it has been abundantly clear that older adults are at substantial risk of severe, even fatal COVID. Yet, the underlying mechanisms for their susceptibility were not always clear despite studies that took co-morbidities into account, like diabetes, heart and lung disorders, and other chronic vagaries of age that can worsen a bout with an infectious disease.

To date, scientists have blamed a dysregulated immune system, an age-related affinity toward excessive blood clotting, and an overall decline in the key soldiers of the adaptive immune system, T and B cells, to explain increased risks for severe COVID in the aging population. And while all of those factors may play a role, an inevitable question looms large: Why?

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