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Tag: research

Data: Heart-failure patients have 82% better odds of living longer if vaccinated against COVID

The first study of COVID-19 vaccine effectiveness in a large population of adult heart-failure patients suggests that vaccinated participants are 82% more likely to live longer than their unvaccinated peers, according to an analysis presented over the weekend at the Heart Failure 2024 scientific congress of the European Society of Cardiology (ESC) in Lisbon, Portugal.

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CDC launching wastewater dashboard to track bird flu virus spread

Reluctance among dairy farmers to report H5N1 bird flu outbreaks within their herds or allow testing of their workers has made it difficult to keep up with the virus’s rapid spread, prompting federal public health officials to look to wastewater to help fill in the gaps.

On Tuesday, the Centers for Disease Control and Prevention is expected to unveil a public dashboard tracking influenza A viruses in sewage that the agency has been collecting from 600 wastewater treatment sites around the country since last fall.

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Researchers estimate vaccines have saved 154 million lives over past half-century

An international team of health and medical researchers including workers at the WHO, working with economists and modeling specialists, has found that the use of vaccines to prevent or treat disease has saved the lives of approximately 154 million people over the past half-century.

In their study, published in The Lancet, the group used mathematical and statistical modeling to develop estimates for lives saved due to vaccines and then added them together to find the total.

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What are the most reliable rapid antigen tests?

A new study has analysed 26 RATs from Australia and Canada, finding only six could effectively detect the lowest concentrations of COVID-19.

Patients across the globe have come to rely on rapid antigen tests (RATs) to confirm a COVID-19 diagnosis, but a new Australian study has revealed most are not producing accurate results.

Researchers from James Cook University (JCU) say they were left ‘shocked’ after an analysis of 26 RATs from Australia and Canada found just six were effective at detecting the lowest concentration of COVID-19.

One Canadian test failed to detect the COVID-19 protein entirely at any level of concentration.

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Scientists, clinicians across Canada preparing for future pandemic threats

Nearly $574 million will be doled out to researchers across the country for projects aimed at ramping up Canada’s preparedness for future health emergencies, including the next pandemic, the federal government announced on Monday.

One of the 19 projects is a national network of existing emergency departments and primary-care clinics, called Prepared, that will screen for any new viruses or pathogens that start to appear in patients.

“As a public health specialist and as a practising physician, I would very much anticipate there being another respiratory pandemic in the future. The challenge is we don’t know when it will be or what it will be,” said Dr. Andrew Pinto, Prepared project lead and a family physician at St. Michael’s Hospital in Toronto.

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Common diabetes drug lowers SARS-CoV-2 levels, clinical trial finds

Today, researchers from the University of Minnesota published evidence that the common diabetes drug metformin decreases the amount of SARS-CoV-2 in the body and helps reduce the risk of rebound symptoms if given early in the course of non-severe illness.

The study, published in Clinical Infectious Diseases, suggests metformin may also help prevent long COVID.

The researchers tested metformin against a placebo in 999 adults infected with COVID-19. More than 50% of the study enrollees were vaccinated, and treatment took place when the Omicron variant was the most dominant strain in the United States.

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International study highlights best RATs

A ground-breaking study by James Cook University researchers has produced damning findings on several COVID-19 Rapid Antigen Tests (RATs) available in Australia and overseas.

The new joint study by JCU and National Research Council Canada analysed 16 RATs approved by Australia’s Therapeutic Goods Administration (TGA) and 10 by Health Canada, using a JCU-developed COVID-19 protein and its Canadian counterpart as reference materials.

Out of the total 26 RATs compared, only six were found to be effective at detecting the lowest concentration of the COVID-19 reference proteins in the dilution series used for benchmarking.

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What we’re starting to learn about H5N1 in cows, and the risk to people

The H5N1 bird flu virus has been around for decades, and the damage it wreaks on chickens and other poultry is well documented. But the recent discovery that the virus has jumped into dairy cattle — whose udders seem to be where the virus either infects or migrates to — has dumbfounded scientists and agricultural authorities.

Questions for which there are pretty clear answers when it comes to birds are suddenly unsettled science in cows. How are they getting infected? Are they transmitting the virus cow to cow, or are human actions — activities that are part of the day-to-day of farming — serving as an unrecognized amplifier of viral transmission? In the interface between infected cows and humans, how might people be at risk? Does consuming milk laced with live H5 virus pose a hazard?

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Scientists discover higher levels of CO2 increase survival of viruses in the air and transmission risk

A new study has revealed for the first time the vital role carbon dioxide (CO2) plays in determining the lifespan of airborne viruses – namely SARS-CoV-2, the virus that causes COVID-19.

It clearly showed keeping CO2 levels in check helps to reduce virus survival, and therefore the risk of infection.

The research, led by the University of Bristol and published today in Nature Communications, shows how CO2 is a major factor in prolonging the life of SARS-CoV-2 variants present in tiny droplets circulating in the atmosphere.

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Video | Akiko Iwasaki on what causes long COVID, brain fog, the Yale Paxlovid study and long COVID treatments

What causes long COVID? Is long COVID dangerous? Who is most likely to get long COVID? Any pediatric long COVID news? What can be done for long term COVID?

Our guest is Akiko Iwasaki, PhD, Sterling Professor of Immunobiology at Yale University. AMA Chief Experience Officer Todd Unger hosts.

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Covid-19 Found in People’s Blood Months After Infection

Key points

  • A quarter of people had Covid-19 viral proteins in their blood up to 14 months after infection.
  • These proteins in the blood indicate that SARS-CoV-2 keeps living in tissue reservoirs.
  • The study used a research-grade test that is not available outside of research labs.
  • The strongest evidence to date that Covid-19 persists in the body provides an important clue to Long Covid.
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COVID-19 virus disrupts protein production, study finds

When SARS-CoV-2 enters our cells, it disrupts the process of making proteins, which are essential for our cells to work correctly. A particular SARS-CoV-2 protein called Nsp1 has a crucial role in this process. It stops ribosomes, the machinery that makes proteins, from doing their job effectively. The virus is like a clever saboteur inside our cells, making sure its own needs are met while disrupting our cells’ ability to defend themselves.

— Talya Yerlici, a post-doctoral researcher at the University of Toronto’s Temerty Faculty of Medicine
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Scientists say USDA is sharing too little data too slowly on H5N1 flu

When the US Department of Agriculture announced late Sunday that it had publicly posted new data from its investigation into a bird flu outbreak in cattle, scientists eagerly searched a well-known platform used globally to share the genetic sequences of viruses.

The sequences weren’t there. As of Tuesday morning, they still aren’t.

Researchers looking to track the evolution and spread of H5N1 say the information that was posted — raw data on a US server — isn’t very useful and is anything but transparent. They also say the government’s release of information in the outbreak, which was confirmed in cattle almost a month ago, has been painfully slow.

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COVID Patient’s Infection Lasts Record 613 Days—and Accumulated Over 50 Mutations

A Covid-19 patient with a weakened immune system incubated a highly mutated novel strain over 613 days before succumbing to an underlying illness, researchers in the Netherlands found.

The patient, a 72-year-old man with a blood disorder, failed to mount a strong immune response to multiple Covid shots before catching the omicron variant in February 2022. Detailed analysis of specimens collected from more than two dozen nose and throat swabs found the coronavirus developed resistance to sotrovimab, a Covid antibody treatment, within a few weeks, scientists at the University of Amsterdam’s Centre for Experimental and Molecular Medicine said. It later acquired over 50 mutations, including some that suggested an enhanced ability to evade immune defenses, they said.

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Remdesivir tied to 25% lower risk of in-hospital death in adults with COVID and no added oxygen

The antiviral drug remdesivir cut death rates 17% to 25% in adults hospitalized for COVID-19 who didn’t require supplemental oxygen at admission, suggests a large US study published yesterday in Open Forum Infectious Diseases.

The study, led by researchers from remdesivir (Veklury) developer Gilead Sciences, used a multicenter US hospital billing database to compare rates of in-hospital death among 58,188 patients on room air who received at least one dose of remdesivir within the first 2 days of hospital admission and 17,574 matched patients not given the drug. The drug is most effective when given early in infection, when viral replication is most active.

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Video | Study finds no link between COVID vaccines and fatal heart problems in young people

A new study from the U.S. Centers for Disease Control and Prevention shows there is no evidence to suggest COVID vaccines cause sudden cardiac death or other fatal heart problems in young people.

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Radio | COVID infections are causing drops in IQ and years of brain aging, studies suggest

When COVID-19 first reared its head back in 2019, it brought with it a slew of strange symptoms beyond just respiratory problems. One of the most puzzling symptoms in those early days was something called “brain fog” — cognitive issues like confusion, forgetfulness, and trouble focusing.

And while other symptoms have changed as the virus mutated, brain fog is still a common complaint of COVID sufferers not only during the initial illness, but extending for months or even years afterwards. Several recent studies have been trying to understand exactly what this virus is doing to our brains — and how to stop it.

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