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NIH cuts billions of dollars in biomedical funding, effective immediately

The Trump administration is cutting billions of dollars in biomedical research funding, alarming academic leaders who said it would imperil their universities and medical centers and drawing swift rebukes from Democrats who predicted dire consequences for scientific research.

The move, announced Friday night by the National Institutes of Health, drastically cuts NIH’s funding for “indirect” costs related to research. These are the administrative requirements, facilities and other operations that many scientists say are essential but that some Republicans have claimed are superfluous.

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I Ran U.S.A.I.D. Killing It Is a Win for Autocrats Everywhere.

We are witnessing one of the worst and most costly foreign policy blunders in U.S. history. Less than three weeks into Donald Trump’s second term, he, Elon Musk and Secretary of State Marco Rubio have halted the U.S. Agency for International Development’s aid programs around the world. In so doing, they have imperiled millions of lives, thousands of American jobs and billions of dollars of investment in American small businesses and farms while severely undermining our national security and global influence — all while authoritarians and extremists celebrate their luck.

I am shocked by the gleeful assault perpetrated by our own government against U.S.A.I.D.’s programs and the public servants who work on them. But after running the agency for four years, I am not surprised that the attacks are being cheered by Moscow and Beijing. They understand what those seeking to dismantle the agency are desperate to hide from the American people: U.S.A.I.D. has become America’s superpower in a world defined by threats that cross borders and amid growing strategic competition.

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Saskatchewan government working on COVID vaccination plan after feds discontinue supply

With province[s] now responsible for purchasing COVID-19 vaccines, the Government of Saskatchewan says it’s figuring out what the coming flu season response will be.

The federal government announced in early January that it would stop funding COVID-19 vaccines this year, with provinces and territories now responsible for buying, determining the timing and rollout of the vaccinations.

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Nasal COVID-19 vaccine based on WashU technology to enter U.S. clinical trials

A nasal vaccine for COVID-19 – based on technology developed at Washington University in St. Louis – is poised to enter a phase 1 clinical trial in the U.S. after an investigational new drug application from Ocugen, Inc. was approved by the Food and Drug Administration (FDA). Ocugen, a U.S.-based biotechnology company, licensed the innovative technology from WashU in 2022.

The trial will be sponsored and conducted by the National Institute of Allergy and Infectious Diseases (NIAID), of the National Institutes of Health (NIH). The FDA’s action is a critical first step toward initiation of the phase 1 trial, planned for this spring.

While cases of COVID-19 have fallen dramatically since the early years of the pandemic, the virus continues to circulate and still causes significant illnesses and deaths. The nasal vaccine technology is designed to induce strong immunity in the nose and upper respiratory tract, right where the virus enters the body, thereby potentially stopping transmission of the virus in addition to reducing serious illness and death. Most COVID-19 vaccines are injected into the arm or leg, and while they are effective at reducing illness and death, they do not halt transmission. The new trial will evaluate the safety and efficacy of the vaccine administered via two routes: inhaled into the lungs and sprayed into the nose.

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Deaths predicted amid the chaos of Elon Musk’s shutdown of USAid

The impact of the billionaire’s declaration has been swift and brutal, with food and crucial drugs abandoned in warehouses, vital programmes closed and workers laid off

Critical supplies of life-saving medicines have been blocked and children left without food and battling malnutrition as multiple effects were reported across the globe after Elon Musk resolved to shut down the US government’s pre-eminent international aid agency.

Chaotic scenes were seen in scores of countries as aid organisations warned of the risk of escalating disease and famine along with disastrous repercussions in areas such as family planning and girls’ education, after President Donald Trump’s decision to freeze funding to USAid. In 2023, the agency managed more than $40bn (£32bn).

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Could the Bird Flu Become Airborne?

In early February 2020, China locked down more than 50 million people, hoping to hinder the spread of a new coronavirus. No one knew at the time exactly how it was spreading, but Lidia Morawska, an expert on air quality at Queensland University of Technology in Australia, did not like the clues she managed to find.

It looked to her as if the coronavirus was spreading through the air, ferried by wafting droplets exhaled by the infected. If that were true, then standard measures such as disinfecting surfaces and staying a few feet away from people with symptoms would not be enough to avoid infection.

Dr. Morawska and her colleague, Junji Cao at the Chinese Academy of Sciences in Beijing, drafted a dire warning. Ignoring the airborne spread of the virus, they wrote, would lead to many more infections. But when the scientists sent their commentary to medical journals, they were rejected over and over again.

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A Canadian Province Released a COVID Report Full of Pseudoscience. Who Wrote It, and Why?

Last week the province of Alberta published a report on its pandemic-response calling for COVID vaccines to be restricted to “high-risk groups” and to stop “their use in healthy children and teenagers.” A mix of vaccine skeptics, fringe academics, and a Trump-appointee were behind it.

The report also recommends regulators, namely the province’s medical licensing body, be stripped of powers to discipline doctors who promote risky and ineffective off-label treatments.

The report has garnered nationwide criticism from the scientific and medical communities, with dozens of experts calling on the government to officially dismiss the report in an open letter. Dr. Joss Reimer, president of the Canadian Medical Association, said the report was “an unfortunate use of public dollars” that funneled CAD$2,000,000 into furthering misinformation. She said it will cause harm globally, as it will be referenced in jurisdictions outside of Canada.

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CDC Data Are Disappearing

Last night, scientists began to hear cryptic and foreboding warnings from colleagues: Go to the CDC website, and download your data now. They were all telling one another the same thing: Data on the website were about to disappear, or be altered, to comply with the Trump administration’s ongoing attempt to scrub federal agencies of any mention of gender, DEI, and accessibility. “I was up until 2 a.m.,” Angela Rasmussen, a virologist at the Vaccine and Infectious Disease Organization at the University of Saskatchewan who relies on the CDC’s data to track viral outbreaks, told me. She archived whatever she could.

What they feared quickly came to pass. Already, content from the CDC’s Youth Risk Behavior Surveillance System, which includes data from a national survey, has disappeared; so have parts of the Agency for Toxic Substances and Disease Registry’s Social Vulnerability Index and the Environmental Justice Index. The CDC’s landing page for HIV data has also vanished. And the agency’s AtlasPlus tool, which contains nearly 20 years of CDC surveillance data on HIV, hepatitis, sexually transmitted infections, and tuberculosis, is down. Several scientists I talked with told me they had heard directly from contacts at the CDC that the agency has directed employees to scrub any mention of “gender” from its site and the data that it shares there, replacing it with “sex.”

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RFK Jr. kept asking to see the science that vaccines were safe. After he saw it, he dismissed it

WASHINGTON (AP) — The man who hopes to be President Donald Trump’s health secretary repeatedly asked to see “data” or “science” showing vaccines are safe – but when an influential Republican senator showed him evidence, he dismissed it.

Robert F. Kennedy Jr. spent two days this week insisting to senators that he’s not anti-vaccine. He said that he instead supports vaccinations and will follow the science in overseeing the $1.7 trillion Department of Health and Human Services, which, among other duties, oversees vaccine research, approval and recommendations.

But Kennedy repeatedly refused to acknowledge scientific consensus that childhood vaccines don’t cause autism and that COVID-19 vaccines saved millions of lives, and he falsely asserted the government has no good vaccine safety monitoring. While appearing to ignore mainstream science, he cited flawed or tangential research to make his points, such as suggesting Black people may need different vaccines than whites.

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People need to ‘remain vigilant’ as measles cases rise, Waterloo region’s medical officer says

While international travel was the initial source of these outbreaks, all the people with recent measles infections were exposed to the virus in Canada.

The majority of measles cases reported in Canada occur among unvaccinated people, many of whom are children and include infants under the age of one who are more vulnerable and have not yet had the opportunity to be vaccinated… that is why we need to remain vigilant and I recommend that we keep up-to-date with the recommended vaccinations.

— Dr. Hsiu-Li Wang, Medical Officer of Health for Waterloo Region
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COVID-19 linked to increase in biomarkers for abnormal brain proteins

Researchers have uncovered a link between COVID-19 and blood markers linked to faulty proteins in the brain.

In an analysis led by researchers at Imperial College London and the UK Dementia Research Institute, scientists found that people who had previously had COVID-19 were more likely to have increased levels of biomarkers linked to faulty amyloid proteins – a known hallmark for Alzheimer’s disease.

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Measles outbreak declared in southwestern Ontario

Public health officials said they are now dealing with a measles outbreak in southwestern Ontario, with 19 confirmed cases as of Jan. 29.

Southwestern Public Health, which covers Oxford County, Elgin County and the City of St. Thomas, is reporting three cases of the highly contagious disease in children.

The remaining 16 infections are with Grand Erie Public Health, which serves the City of Brantford, Brant County, Haldimand County and Norfolk County. In an update Friday, officials said thirteen children and three adults have measles.

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Kennedy faces tough questioning on vaccine views at HHS confirmation hearing

RFK Jr. has a well-documented history of spreading dangerous disinformation on vaccines and public health interventions, leaving vulnerable communities unprotected and placing millions of lives at risk. His appointment is a direct threat to the safety of our patients and the public at large.

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‘Bad science’: Academics tear apart Alberta’s $2-million report on COVID

False narratives in a new $2-million report on COVID 19 in Alberta send Albertans the wrong signals, said a former chief medical officer of health for the province.

An adjunct professor at the University of Alberta’s School of Public Health, Dr. James Talbot said the 269-page report released late last Friday cherry-picks information and includes unproven ideas, including that the vaccine is ineffective and potentially harmful.

“We’ve given literally billions of doses of this vaccine around the world with the best surveillance we’ve ever had. This is one of the safest, most effective vaccines that we’ve ever had,” he said.

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Tracking diseases from the sewer

The European Commission has just launched a new tool that supports the tracking of the spread of infectious diseases by analysing wastewater: the European Wastewater Surveillance Dashboard. It displays data from across the EU by bringing together existing national and research-based dashboards.

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Video | Caroline Kennedy accuses cousin RFK Jr. of being a ‘predator’

CNN’s Arlette Saenz reports on video shared by Caroline Kennedy warning senators to reject her cousin Robert F. Kennedy Jr.’s nomination to be Health and Human Services secretary ahead of confirmation hearings on Wednesday.

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VIDO funded $24M to help develop ‘holy grail’ coronavirus vaccine

The Vaccine and Infectious Disease Organization (VIDO) at the University of Saskatchewan has been awarded a $24 million grant to help develop a vaccine to protect against wide-ranging strains of coronaviruses.

VIDO’s funding flows from Norwegian-based Coalition for Epidemic Preparedness Innovations (CEPI) into its ongoing development of its pan-sarbecovirus vaccine.

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Trump Administration Halts H.I.V. Drug Distribution in Poor Countries

The Trump administration has instructed organizations in other countries to stop disbursing H.I.V. medications purchased with U.S. aid, even if the drugs have already been obtained and are sitting in local clinics.

The directive is part of a broader freeze on foreign aid initiated last week. It includes the President’s Emergency Plan for AIDS Relief, the global health program started by George W. Bush that is credited with saving more than 25 million lives worldwide.

The administration had already moved to stop PEPFAR funding from moving to clinics, hospitals and other organizations in low-income countries.

Appointments are being canceled, and patients are being turned away from clinics, according to people with knowledge of the situation who feared retribution if they spoke publicly. Many people with H.I.V. are facing abrupt interruptions to their treatment.

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