The updated 2024-25 COVID-19 vaccines provided 57% protection against hospitalization and death, although their effectiveness waned over time, according to a study yesterday in JAMA Internal Medicine.

The study assessed effectiveness against infection, emergency department (ED) visits, and hospitalization. Protection against infection and ED visits was 45%.

The study was based on outcomes seen among Nebraskan residents during the 2024-25 respiratory virus season and used hospital discharge data from member hospitals of the Nebraska Hospital Association and data from death certificates from the Nebraska Office of Vital Records.